Formulation and Evaluation of a Syrup Based on Balanites aegyptiaca L. Delile

Introduction: The kernel powder of the fruit of Balanites aegyptiaca (L.) Del is mixed with sorghum flour for the treatment of intestinal worms in Burkina Faso. Previous preclinical studies have demonstrated the efficacy and safety of the medicine.

Objective: The objective of this study is to execute galenic formulations based on extracts of the kernel of the fruit of Balanites aegyptiaca (L.) with good pharmaceutical quality.

Methods: The quality control was carried out for the freeze-dried extracts of kernels and the syrups were prepared thereon. Thin layer chromatography has been used to characterize the chemical constituents. Syrups were prepared from lyophilized aqueous extracts. Fifteen (15) test formulationswere prepared and the quality control of these samples helped to sort out only one best among them.

Results and Discussion: The results show that the syrups had a good appearance without sedimentation, it was easy to disperse and, it showed absence of Salmonella and coliforms. Stability studies showed that after two years’ of storage, the syrups kept the same colors, taste and were free of mold. The chemical composition of the syrup was similar during the studied storage time. Assessments of bacterial contamination of syrups showed an absence of Salmonella and coliforms. After two years of storage they have maintained a good microbiological quality.

Conclusion: This study made it possible to ensure good quality of the syrups prepared. Parameters studied can be used routinely as elements of evaluation and quality control.