Physiocochemical Standardization and Formulation Development of Poly-herbal Tablet for Diabetes

Diabetes is one of the leading health problems in the current world population. Very near future India will be the capital of Diabetes mellitus (DM).

Objective: The objective of this present study was to develop and evaluate polyherbal tablet for diabetes. Developing herbal formulations for oral usages is still a challenge in modern pharmaceutical aspects and the tablet formulation presents many technical problems to the industrial pharmacist.

Methods: Potential anti-diabetic herbs were used for developing tablets. Phytochemical parameters for standardization of plants were, according to standard methods and aqueous extract of the whole plant of Cassia auriculata, Cinnamomum tamala, Ficus benghalensis, Mangifera indica and Trichosanthes dioica were used in the formulations. Pre-formulations studies were performed for powder blends. Drug excipients compatibility and microbiological limits were also evaluated.

Results: All the tablets were prepared by using hand rotating single punch tablet punching machine and were evaluated for various tablet compression parameters, i.e. tab densities, bulk densities, an angle of repose, general appearance, weight uniformity, hardness, friability, and disintegration. All formulations are found to be nil or under the standard limit.

Conclusion: The laboratory scale preparation of poly-herbal tablet may lead to a new potent and stable oral dosage formulations for DM and enlighten the area of synergistic action of herbs.