Multi-Biomarker-Based Risk Assessment Model: Implications in Patients with Hypertensive Heart Disease

Systemic hypertension is a leading cause of morbidity and mortality worldwide. Primary and secondary prevention of cardiovascular adverse events are limited by the generally poor predictive value of traditional risk factors assessment models. The use of tissue-specific cardiac biomarkers that can reliably assess pathologic conditions is important for early detection and prevention of target organ damage. This review article highlights the role of multi-biomarker models in providing insight to greater understanding of the pathophysiological mechanisms and their implications on cardiovascular morbidity in systemic hypertension.